The USC Upstate College Excellence Fund supports all aspects of the University and is the primary channel for donors to support the University’s greatest needs. Gifts to this fund are used to support various initiatives and programs across campus. Additionally, the USC Upstate Excellence Fund allows the University to respond quickly to emerging needs or unexpected opportunities, which awards the University with extreme flexibility.

The Athletics Excellence Fund is designed to support the university's athletic programs and student-athletes by providing scholarship support, facility and equipment upgrades, and program support. Unrestricted gifts to this fund allow the Upstate Athletic department the flexibility to direct funds where they are most needed in athletics.

The College of Arts, Humanities, and Social Science Excellence Fund provides support to the University’s fine and performing arts, humanities, and social sciences. Donations to this Excellence Fund allow this program to continue offering a mix of traditional liberal arts with innovative problem-solving skills for students. The flexibility of this fund grants faculty the ability to expand their teachings through engaging dialogue, critical thinking, and compassionate instruction, that has a direct impact on students.

The Mary Black College of Nursing Excellence is a fund designed to support the university's nursing program and its students by providing funding for state-of-the-art technology and equipment for nursing students. Unrestricted gifts to this fund allow the College of Nursing the flexibility to direct funds where they are most needed, which ensures nursing students have the resources and opportunities they need to succeed in their studies, in clinical practice, and in their future careers.

The College of Education, Human Performance, and Health Excellence Fund provides support to the University's programs for future educators and health practitioners in the community. Unrestricted gifts to this fund award the students with resources and opportunities they need to succeed in their studies and their future careers, helping to enhance the reputation and profile of the College and supporting the development of future leaders in these fields.

The College of Science and Technology Excellence Fund provides much need unrestricted funding to STEM programs and students. Gifts made to this Excellence Fund awards students with cutting-edge technology in a fast-growing field, all while providing highly qualified faculty and staff with the resources they needed to teach in this field. Additionally, this Excellence Fund gives much needed flexibility in an ever-changing field of study.

The George Dean Johnson, Jr. College of Business and Economics Excellence Fund provides critical support to enhance the student experience by providing the resources necessary for classroom success, internships, and business and economic fields. Donations to this Excellence Fund support a wide range of initiatives that will help students gain the necessary skills and knowledge for the workforce, and help Faculty stay up-to-date on the latest business practices.

The University College Excellence Fund supports the much need for academic support services and special academic programs. This Excellence Fund helps create an exceptional learning experience for students by providing educational and career resources.

The University College Excellence Fund supports the need for academic support services and special academic programs. This Excellence Fund helps create an exceptional learning experience for students by providing educational and career resources.